Diff'rent Strokes

Two orphaned brothers, Arnold & Willis Jackson, are adopted by wealthy Manhattan widower Phillip Drummond when their mother (Drummond's maid) passes away. Along with Drummond's daughter Kimberly & housekeeper Mrs. Garrett, this family sitcom covers topics such as wealth- & racial- inequality.
This was Gary Coleman's breakout role as short but sassy Arnold, whose catchphrase "What'choo talkin' 'bout?" became a national trend.