Sergio is in trouble because the body of a woman was discovered in his house. Anna believes in the innocence of the man, but the prosecutor Nardi is not entirely convinced. Meanwhile, the Canonica is in turmoil: the Pope has proposed to Don Matteo to become a Cardinal. For Natalina, Pippo and Nino it is a hard blow and the only way not to make him leave for Rome is to "boycott" Don Matteo and put him in a bad light in front of the Apostolic Nuncio.