Nova

Ty Glaser

Marie Anne Lavoisier

Bohdan Poraj

Francis Crozier

Corey Conradi

Roald Amundsen

Darri Ingolfsson

Godfred Hansen

Marian Tomas Griffin

Mary Mallon

Jere Shea

George Soper

Natalie Rose

Josephine Baker

Keith David

Narrator

Calvin Sims

Reporter

C. Scott Willis

Reporter

Simon Callow

Galileo

Laura Nardi

Maria Celeste

John Fraser

Inquisitor

Alexa Jago

Voice of Maria Celeste

Thom Fell

James Fitzjames

Maureen Bennett

Lady Franklin

Brendan Fleming

Hermann Einstein

Stephen Noonan

Marat

Anton Lesser

Voltaire

Emily Woof

Lise Meitner

Alex MacQueen

Chater

Samuel West

Humphry Davy

Robert Styles

Newman

Philip Herbert

Count de Amerval

Di Trevis

Baroness de la Garde

James Tovell

Manson

F. Murray Abraham

Narrator

Scott Handy

Isaac Newton

Anthony Garner

Sir John Franklin

Cornelius Garrett

Voices of the Ambassador and Castelli

Sigourney Weaver

Narrator

Richard Allinson

Narrator

Lee Rogers Berger

Himself

Zeresenay Alemseged

Himself

John Hawks

Himself

Zachary Quinto

Narrator

Laurence Golborne

Self

Robert Michelson

Self

Reinhard Genzel

Self

Manfred von Richthofen

Self (archive footage)

William H. Whyte

Self

James R. Schlesinger

Self (archive footage)

Heather Berlin

Self

George Pataki

Self

Jan Maxwell

Narrator

Jeremy Akerman

Parslow

Rena Baskin

Narrator

Vladimir Pozner

Host

Roger McGough

Narrator

William Hootkins

Voice of Methuselah

Derek Jacobi

Voice of Ernest Shackleton

Ian Holm

Narrator

Susan Sarandon

Narrator (voice)

Hector Elizondo

Narrator

Robert Krulwich

Correspondent

Hal Linden

Narrator

John Hurt

Narrator

Rebecca De Mornay

Narrator

Sally Kellerman

Narrator

John E. Mack

Self - Psychiatry, Harvard Medical School

Julian Rhind-Tutt

Antoine Lavoisier

Jay O. Sanders

Narrator / Narrator (voice)

Gene Galusha

Narrator

Jeremiah Kissel

Narrator

Demetri Goritsas

Narrator

Ted Marcoux

Narrator

Richard Smith

Host

Talithia Williams

Self - Narrator

David Attenborough

Narrator

Joe Morton

Additional Narration / Narrator

Roy Scheider

Narrator

John Hockenberry

Narrator

Kirk Johnson

Host

John Mckenzie

Narrator

Salvatore Vecchio

Narrator

Richard Donat

Narrator

Peter Thomas

Narrator

Lance Lewman

Narrator (voice)

Craig Sechler

Narrator

David Pogue

Host

Neil Ross

Narrator

Liev Schreiber

Narrator (voice)

Will Lyman

Narrator

David Ogden Stiers

Narrator

Corey Johnson

Narrator

John Lithgow

Narrator

Brian Greene

Host

Stacy Keach

Narrator

Neil deGrasse Tyson

Host / Narrator

Jamie Effros

Narrator

Stockard Channing

Bible Reader / Narrator

Christian Pedersen

Gustav Wiik / Otto Hahn

Mark Oliver Everett

Himself

Stefanie E. Frame

Narrator

John Benjamin Hickey

Narrator

Alan Yentob

Narrator

Rob Tinworth

Narrator

David Slavin

Narrator

Ray Magliozzi

Host

Tom Magliozzi

Host

Harrison Ford

Narrator

E.O. Wilson

Himself

Ruben Santiago-Hudson

Percy Julian

Aidan McArdle

Albert Einstein

Shirley Henderson

Mileva Maric

Rushmore DeNooyer

Narrator

Nigel Bennett

Sir Charles Lyell

Kathryn Walker

Narrator

Oliver Platt

Narrator

Edd Gasper

Narrator

Tony Kahn

Narrator

Courtney B. Vance

Narrator

Bray Poor

Narrator

Michael Scott

Narrator

Jim Carter

Narrator

Kenichi Nakamaru

Reporter

Shu Morino

Reporter

Eric Meyers

Narrator

Henry Ian Cusick

Charles Darwin

Frances O'Connor

Emma Darwin

Steven Robertson

Michael Faraday