While Anna and Marco are struggling with the organization of their wedding, Andrea, the son of a famous heart surgeon from Spoleto, is kidnapped. Anna, in addition to finding the baby, will have to solve a professional issue that has tormented her for months and risks becoming an obstacle to marriage. Meanwhile, a bizarre treasure hunt puts Spoleto in turmoil: everyone is looking for the money left by a mysterious benefactor, thousands of euros enclosed in boxes accompanied by origami. Is it simply a game? What if someone took advantage of the confusion to hurt Don Matteo?