Dog City

The animated portions of the show focused on a canine private investigator named Ace Hart. The Muppet portions of the show focused on the interactions between Ace Hart and his animator Eliot Shag (who, like Ace, is a German Shepherd). Eliot would illustrate the stories while Ace would go traverse through it, occasionally breaking the fourth wall to speak with Eliot about the various troubles with the story. In one episode, Eliot even enters Dog City himself to join Ace in solving a mystery.
A recurring gag was that many of the characters in the cartoon were seemingly based on the residents of Eliot's apartment building. The bulldog crime-boss Bugsy Vile was inspired by the building's grouchy bulldog superintendent Bruno. Ace's love interest Rosie was based on Eliot's unrequited feelings for his neighbor Colleen, and so on. The Muppet characters were unaware of this.