In the near future, the aforementioned civil war leaves Manhattan a demilitarized zone (DMZ), destroyed and isolated from the rest of the world. The series chronicles the harrowing journey of a fierce female medic who saves lives while desperately searching for her lost son. But as she contends with the gangs, militias, demagogues, and warlords that control this lawless no man’s land, she becomes the unlikely source of what everyone here has lost: hope.