Family Guy Presents: Stewie Kills Lois and Lois Kills Stewie

Seth MacFarlane

Peter Griffin / Stewie Griffin / Stan Smith (voice)

Seth Green

Chris Griffin (voice)

Alex Borstein

Lois Griffin (voice)

Mila Kunis

Meg Griffin (voice)

Mike Henry

Cleveland Brown / Bruce / Jeffry / Consuela (voice)

Patrick Warburton

Joe Swanson (voice)

Patrick Stewart

Avery Bullock (voice)

Simon Cowell

Himself (voice)

Paula Abdul

Herself (voice)

Randy Jackson

Himself (voice)

David Boat

Rupert (voice)

Alexandra Breckenridge

Cancer Sufferer (voice) (as Alex Breckenridge)

Phil LaMarr

Judge (voice)

Adam West

Mayor Adam West (voice)

David Anthony Pizzuto

Willem Dafoe (voice)