Het seizoen 2 van SOKO Stuttgart werd uitgezonden op ZDF van jeudi 7 octobre 2010 tot jeudi 14 avril 2011. Het bestaat uit 25 afleveringen, de eerste heet "Altlasten" en de laatste "Das Todesfagott".
Stuttgart is a town whose social, economic and cultural contrasts sometimes can't be reconciled without violence. It's a place that needs a special crime squad: Stuttgart Homicide. The team knows its turf inside out and glides smoothly from one level of society to another: from illegal betting clubs to mafia extortionists, from greedy quality inspectors to thieving firemen, and from fanatical Christians to bedridden mothers who can't die soon enough for their loved ones …