Astro Boy

Nicolas Cage

Dr. Tenma (voice)

Madeline Carroll

Widget (voice)

Freddie Highmore

Astro Boy (voice)

Kristen Bell

Cora (voice)

Donald Sutherland

General Stone (voice)

Bill Nighy

Dr. Elefun (voice)

Eugene Levy

Orrin (voice)

Sterling Beaumon

Sludge (voice)

Nathan Lane

Ham Egg (voice)

Samuel L. Jackson

Zog (voice)

Charlize Theron

Narrator

David Alan Grier

Mr. Squirt / Math Cowboy / Boxer Robot

Alan Tudyk

Mr. Squeegee / Scrapheap Head / Stinger Two

Newell Alexander

General Heckler (voice)

Elle Fanning

Grace (voice)

Pilar Flynn

Cora's Mom (voice)

Dee Bradley Baker

Trashcan (voice)

Moisés Arias

Zane (voice)

Ryan Stiles

Mr. Moustachio/Burning Robot (voice)

Matt Lucas

Sparx (voice)

David Bowers

Mike the Fridge (voice)

Sofia Bowers

The Little Stinker (voice)

Nicole Fletcher

Oh No! Kid (voice)

Maryann Garger

Dr. Pigknuckle / Newscaster (voice)