Dr John Meredith, ashamed at the crime spree of his twin, Bradley, travels with his daughter, Nyoka, to Africa. There his skills as a doctor displace Shamba, the resident Witch Doctor of the Masamba. Years later, Slick Latimer and Bradley Meredith arrive looking for a local diamond mine and team up with the disgruntled Shamba. Bradley kills his brother John and takes his place. Fortunately, they also brought along Jack Stanton and Curly Rogers, who promptly join Nyoka in trying to stop the villains.